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The gamete fusion process is defective in eggs of Cd9-deficient mice

✍ Scribed by Uematsu, Yoshikatsu; Sakagami, Junko; Tada, Norihiro; Miyazaki, Shunichi; Kaji, Keisuke; Oda, Shoji; Shikano, Tomohide; Ohnuki, Tatsuya; Kudo, Akira


Book ID
109827764
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
443 KB
Volume
24
Category
Article
ISSN
1061-4036

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CD22 is an inhibitory coreceptor for B cell receptor (BCR) signaling. The inhibition is most likely mediated by activation of SHP-1. We found that SLP65/BLNK reaches maximal tyrosine-phosphorylation at earlier time points in CD22(-/-) than in wild type B cells upon BCR cross-linking, suggesting that