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Experimental Documentation of the Structural Consequences of Hydrogen-Bonding Interactions to the Proximal Cysteine of a Cytochrome P450

โœ Scribed by Dr. Piotr J. Mak; Dr. Yuting Yang; Dr. Sangchoul Im; Prof. Lucy A. Waskell; Prof. James R. Kincaid

Book ID
115549870
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
608 KB
Volume
124
Category
Article
ISSN
0044-8249

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โœ David Fโ€ŠV Lewis ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› Wiley (John Wiley & Sons) ๐ŸŒ English โš– 152 KB

## Abstract An overview of the COMPACT method for evaluating potential toxicity mediated by cytochrome P450 enzymes is presented. Particular aspects of P450s are described, together with details of QSARs and homology modelling of mammalian P450s associated with foreign compound metabolism. ยฉ 2001