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COMPACT: a structural approach to the modelling of cytochromes P450 and their interactions with xenobiotics

✍ Scribed by David F V Lewis

Publisher: Wiley (John Wiley & Sons)
Year: 2001
Tongue: English
Weight: 152 KB
Volume: 76
Category: Article
ISSN: 0268-2575
DOI: 10.1002/jctb.363

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✦ Synopsis

Abstract

An overview of the COMPACT method for evaluating potential toxicity mediated by cytochrome P450 enzymes is presented. Particular aspects of P450s are described, together with details of QSARs and homology modelling of mammalian P450s associated with foreign compound metabolism.

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