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Experimental basis for the antidepressant action of the GABA receptor agonist progabide

✍ Scribed by Bartholini, Giuseppe


Book ID
123079326
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
283 KB
Volume
47
Category
Article
ISSN
0304-3940

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The anticonvulsant action of progabide, an agonist of gamma-aminobutyric acid (GABA)A and GABAB receptors, was investigated in the kindling model of epilepsy in rats. Progabide shortened afterdischarge durations and attenuated the severity of the accompanying convulsive responses in previously kindl