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An analysis of the actions of progabide, a specific GABA receptor agonist, on kindling and kindled seizures

✍ Scribed by Robert M. Yoy; Timothy E. Albertson; Larry G. Stark


Book ID
115897713
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
642 KB
Volume
83
Category
Article
ISSN
0014-4886

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The anticonvulsant action of progabide, an agonist of gamma-aminobutyric acid (GABA)A and GABAB receptors, was investigated in the kindling model of epilepsy in rats. Progabide shortened afterdischarge durations and attenuated the severity of the accompanying convulsive responses in previously kindl