Experimental and Theoretical Studies of Sodium Cation Complexes of the Deamidation and Dehydration Products of Asparagine, Glutamine, Aspartic Acid, and Glutamic Acid
β Scribed by Heaton, A. L.; Ye, S. J.; Armentrout, P. B.
- Book ID
- 118029437
- Publisher
- American Chemical Society
- Year
- 2008
- Tongue
- English
- Weight
- 232 KB
- Volume
- 112
- Category
- Article
- ISSN
- 1089-5639
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π SIMILAR VOLUMES
In this study, the polypeptide hormone glucagon was used as a model to investigate the mechanisms of aspartic acid cleavage and glutaminyl deamidation in acidic aqueous solutions. Kinetic studies have shown that cleavage at Asp-21 occurred at significantly slower rates than at Asp-9 and Asp-15 while
Raman spectroscopy and the self-consistent reaction Γeld (SCRF) theory were used to study structural and vibrational features of the amino acid L-asparagine in and solutions. Ab initio methodology at the RHF/6-H 2 O D 2 O 31 + G\* level were used to evaluate the minimum energy structure, quadratic f