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Experimental and Theoretical Evidence for a Concerted Catalysis by Water Clusters in the Hydrolysis of Isocyanates

โœ Scribed by Raspoet, Greet; Nguyen, Minh Tho; McGarraghy, Michelle; Hegarty, Anthony Frank


Book ID
121208186
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
304 KB
Volume
63
Category
Article
ISSN
0022-3263

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## Abstract Recent theoretical studies of the alkaline hydrolysis of the amide bond have indicated that the nucleophilic attack of the hydroxide ion at the carbonyl carbon of the amide group is rate limiting. This is shown to be inconsistent with a large amount of experimental observations where th