Experimental and Computational Studies of Epithelial Transport of Mefenamic Acid Ester Prodrugs
β Scribed by Kamonthip Wiwattanawongsa; Vimon Tantishaiyakul; Luelak Lomlim; Yon Rojanasakul; Sirirat Pinsuwan; Sanae Keawnopparat
- Book ID
- 106492545
- Publisher
- Springer US
- Year
- 2005
- Tongue
- English
- Weight
- 114 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0724-8741
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The triphenyltin adduct of mefenamic acid, [SnPh 3 L] (1), the monophenyltin complex [PhSnOL] n (2), and the dibutyltin complex [SnBu 2 L 2 ] (3), where HL is 2-[bis(2,3-dimethylphenyl)amino]benzoic acid (mefenamic acid), have been prepared and structurally characterized by means of vibrational, 1 H
The purpose of this study is to assess the permeability of acyclovir (ACV) prodrugs through the rabbit corneal cell line (SIRC) as well as the cornea, and characterize the SIRC cell line for transport and metabolism studies of ester prodrugs. Prodrug derivatization of an acycloguanosine antiviral ag