The objective of this study was to investigate the mechanisms by which berberine is transported in the secretory and absorptive directions across Caco-2 cell monolayers. The basolateral-to-apical (B-A) flux was 30-fold greater than the apical-to-basolateral flux and temperature dependent (i.e., dras
Characterization of Mefenamic Acid-Guaiacol Ester: Stability and Transport Across Caco-2 Cell Monolayers
โ Scribed by Vimon Tantishaiyakul; Kamonthip Wiwattanawongsa; Sirirat Pinsuwan; Srirat Kasiwong; Narubodee Phadoongsombut; Sanae Kaewnopparat; Nattha Kaewnopparat; Yon Rojanasakul
- Book ID
- 110348506
- Publisher
- Springer US
- Year
- 2002
- Tongue
- English
- Weight
- 91 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0724-8741
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## Abstract The transport and uptake of individual propranolol (PPL) enantiomers were studied in human intestinal Cacoโ2 cell monolayers, and a reversedโphase HPLCโUV assay was used for quantitative analysis. SโPPL and RโPPL across Cacoโ2 cell monolayers was determined in the concentrations range o
The kinetics of transport of a new fluoroquinolone antibiotic (CNV97100) and its analogs were characterized using the Caco-2 cell culture model. Unidirectional permeabilities of these analogs were greater (p < 0.05) than that of ciprofloxacin. The absorptive permeabilities (P(AB)) of 4'-N-substitute