Experience with high dose methotrexate therapy in childhood acute lymphoblastic leukemia in a tertiary care cancer centre of a developing country
β Scribed by Gauri Kapoor; Rupal Sinha; Sarfraz Abedin
- Book ID
- 112168084
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 166 KB
- Volume
- 59
- Category
- Article
- ISSN
- 1545-5009
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π SIMILAR VOLUMES
High-dose methotrexate (HDMTX, 1,000 mg/m2) and cranial irradiation/sequential chemotherapy (RTSC) were compared for ability to extend complete remission durations in children with acute lymphoblastic leukemia (ALL). Three hundred thirty patients were enrolled in the study, according to our criteria
Methotrexate (MTX) infusions of 500-1,000 mg/m2 over 24 hours may improve survival and prevent relapse in children with acute lymphoblastic leukemia (ALL). Childrens Cancer Group (CCG) Study 139 compared weekly oral methotrexate 20 mg/m2/ week (oral MTX) to MTX 500 mg/m2 infused over 24 hours (IV MT