Expeditious synthesis of helianane and C-10 halogenated heliananes employing ring-closing metathesis

✍ Scribed by Subir Sabui; Subrata Ghosh; Debayan Sarkar; Ramanathapuram V. Venkateswaran

• Publisher: Elsevier Science
• Year: 2009
• Tongue: French
• Weight: 198 KB
• Volume: 50
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2009.06.001

✦ Synopsis

An expeditious synthesis of the marine sesquiterpene helianane enclosing an unusual benzoxocane ring system is described employing ring-closing metathesis as the key step. Helianane has been further converted to the naturally occurring C-10 bromo and chloro derivatives.