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Expeditious preparation of 2-substituted quinolines

✍ Scribed by Mohamed A Fakhfakh; Xavier Franck; Alain Fournet; Reynald Hocquemiller; Bruno Figadère

Book ID
104230670
Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
73 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

A library of 2-substituted quinolines was synthesized in solution from mixtures of Grignard reagents and a quinolinium salt. Grignard reagents were prepared in one pot, taking advantage of the entrainment method for their preparation from unreactive alkyl halides. Then mixtures of 2-alkylquinolines were readily accessible for biological tests or separated by centrifugal-partition chromatography (CPC) prior to the biological screening.

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✍ Minoo Khazan; Farzin Hadizadeh; Abbas Shafiee 📂 Article 📅 1997 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 326 KB

## Abstract Reaction of methyllithium with 1‐methy1‐2‐imidazolecarboxaldehyde afforded the corresponding alcohol 2. Oxidation of compound 2 with manganese dioxide gave 2‐acety1‐1‐methylimidazole (3). Using compound 3 and substituted isatins 4, the corresponding quinoline‐4‐carboxylic acids (5) were