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Expedient Synthesis of α-Substituted α, β- Unsaturated γ-Amino Acids (Dipeptide Mimetics); Wittig Reaction of α-Amino Aldehydes with α- Substituted Alkoxycarbonyl Phosphoranes

✍ Scribed by Scholz, Dieter; Weber-roth, Sabine; Macoratti, Elena; Francotte, Eric


Book ID
127008796
Publisher
Taylor and Francis Group
Year
1999
Tongue
English
Weight
425 KB
Volume
29
Category
Article
ISSN
0039-7911

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The Rh-DuPHOS and Rh-BPE catalyzed hydrogenation of IS-substituted ¢x,[~,y,8-unsaturated amino acids establishes two contiguous stereogenic centers simultaneously. Both high regioselectivity and good to excellent enantioselectivity have been demonstrated in this process leading to I~-branched allyl