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Asymmetric Wolff Rearrangement Reactions with α-Alkylated-α-diazoketones: Stereoselective Synthesis of α-Substituted-β-amino Acid Derivatives †

✍ Scribed by Yang, Hua; Foster, Katherine; Stephenson, Corey R. J.; Brown, William; Roberts, Edward


Book ID
120933726
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
43 KB
Volume
2
Category
Article
ISSN
1523-7060

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Asymmetric synthesis of α,α-disubstitute
✍ Masayuki Matsushita; Hana Maeda; Mitsuaki Kodama 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 211 KB

An efficient route for the asymmetric synthesis of ct,a-disubstituted or-amino acids derivatives (1, 2, and 3) starting from readily available epoxy silyl ethers (6) has been developed. High enantiomeric purity can be realized by the present method using a combination of MABR rearrangement of a chir