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Expedient Synthesis of threo -β-Hydroxy-α-amino Acid Derivatives: Phenylalanine, Tyrosine, Histidine, and Tryptophan

✍ Scribed by Crich, David; Banerjee, Abhisek

Book ID: 118201215
Publisher: American Chemical Society
Year: 2006
Tongue: English
Weight: 95 KB
Volume: 71
Category: Article
ISSN: 0022-3263
DOI: 10.1021/jo061159i

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## Abstract The phenylalanine aminomutase (PAM) from __Taxus chinensis__ catalyses the conversion of α‐phenylalanine to β‐phenylalanine, an important step in the biosynthesis of the __N__‐benzoyl phenylisoserinoyl side‐chain of the anticancer drug taxol. Mechanistic studies on PAM have suggested th