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Expedient Synthesis of a Novel Class of Pseudoaromatic Amino Acids: Tetrahydroindazol-3-yl- and Tetrahydrobenzisoxazol-3-ylalanine Derivatives.

✍ Scribed by Richard J. Middleton; Sarah L. Mellor; Siri Ram Chhabra; Barrie W. Bycroft; Weng C. Chan


Publisher
John Wiley and Sons
Year
2004
Weight
118 KB
Volume
35
Category
Article
ISSN
0931-7597

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An expedient synthesis of (Β±)-2-amino-3-
✍ Robert N. Hanson; Farid A. Mohamed πŸ“‚ Article πŸ“… 1997 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 277 KB

## Abstract The excitatory, amino acid Β±2‐amino‐3‐(3‐hydroxy‐5‐methylisoxazol‐4‐yl)propionic acid hydrobromide was prepared in gram quantities in an 3.3% overall yield from methylbut 2‐ynoate. The key step was the facile preparation of methyl 3‐bromo‐5‐methylisoxazole‐4‐carboxylate.