Expedient Protocol for Solid-Phase Synthesis of Secondary and Tertiary Amines
β Scribed by Olsen, Christian A.; Witt, Matthias; Jaroszewski, Jerzy W.; Franzyk, Henrik
- Book ID
- 118235281
- Publisher
- American Chemical Society
- Year
- 2004
- Tongue
- English
- Weight
- 62 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1523-7060
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π SIMILAR VOLUMES
The clean and efficient cleavage of N-benzyl linked tertiary amines from a solid support (e.g. 4) by treatment with ct-chloroethyl chloroformate (ACE-CI) / methanol to yield secondary amines 7 is described. This allows the solid-phase synthetic transformation of the secondary amine 2 into 7. When th
A novel linker for the solid-phase synthesis of secondary amines based on an intramolecular cyclization was developed. The linker allows for a stepwise built-up of the secondary amines on the support. The feasibility was demonstrated in the parallel synthesis of a small set of different secondary am