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Expansion of unusual CD4+ T cells in severe rheumatoid arthritis

✍ Scribed by Peter B. Martens; Jörg J. Goronzy; Daniel Schaid; Cornelia M. Weyand


Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
874 KB
Volume
40
Category
Article
ISSN
0004-3591

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Objective. To investigate the rheumatoid arthritis (RA)-specific autoantigen(s) recognized by CD4+ T cells in patients with RA. Methods. CD4+,CD45RO+ T cell clones were established from the joints of RA patients, and were examined for their proliferative response to synovial cells. Results. Eight of