## Alpha -galactosylceramide, a glycosphingolipid, mediates interaction of dendritic cells (DCs) and NKT cells, leading to activation of both innate and acquired immunity. For cancer treatment, conventional DC-based vaccine has been tried, but its clinical efficacy is limited against liver cancer.
Expansion of Lung Vα14 NKT Cells by Administration of α-Galactosylceramide-pulsed Dendritic Cells
✍ Scribed by Akutsu, Yasunori ;Nakayama, Toshinori ;Harada, Michishige ;Kawano, Tetsu ;Motohashi, Shinichiro ;Shimizu, Eiko ;Ito, Toshihiro ;Kamada, Noriaki ;Saito, Takeshi ;Matsubara, Hisahiro ;Miyazawa, Yukimasa ;Ochiai, Takenori ;Taniguchi, Masaru
- Book ID
- 108582128
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2002
- Tongue
- English
- Weight
- 678 KB
- Volume
- 93
- Category
- Article
- ISSN
- 0910-5050
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Natural killer T (NKT) cells are a distinct lymphocyte lineage that regulates immune responses. During their development in the thymus, immature uncommitted double-positive CD4 + CD8 + thymocytes that rearrange the semi-invariant T-cell receptor found on mature NKT cells are positively selected by t
## Abstract NKT cell development takes place in the thymus, beginning when these cells branch away from CD4^+^CD8^+^ mainstream thymocytes upon expression of the Vα14Jα18 T cell receptor (TCR) and recognition of the CD1d molecule. Although NKT cells express an invariant TCR α chain, the diverse TCR