Amine Additives Greatly Expand the Scope
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Xavier Verdaguer; Udo E. W. Lange; Stephen L. Buchwald
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Article
📅
1998
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John Wiley and Sons
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English
⚖ 134 KB
👁 2 views
Slow addition of a primary amine to the reaction mixture greatly increases the scope of the titanium-catalyzed asymmetric reduction of imines 1. An important added feature of this method is that chiral secondary amines 2 can be obtained in much higher optical purity (up to 99 % ee) than would be pre