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ChemInform Abstract: Amine Additives Greatly Expand the Scope of Asymmetric Hydrosilylation of Imines.

✍ Scribed by X. VERDAGUER; U. E. W. LANGE; S. L. BUCHWALD

Publisher
John Wiley and Sons
Year
2010
Weight
34 KB
Volume
29
Category
Article
ISSN
0931-7597

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Amine Additives Greatly Expand the Scope
Amine Additives Greatly Expand the Scope of Asymmetric Hydrosilylation of Imines
✍ Xavier Verdaguer; Udo E. W. Lange; Stephen L. Buchwald πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 134 KB πŸ‘ 2 views

Slow addition of a primary amine to the reaction mixture greatly increases the scope of the titanium-catalyzed asymmetric reduction of imines 1. An important added feature of this method is that chiral secondary amines 2 can be obtained in much higher optical purity (up to 99 % ee) than would be pre