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The Scope of the Direct Proline-Catalyzed Asymmetric Addition of Ketones to Imines

✍ Scribed by Wolfgang Notz; Shin-ichi Watanabe; Naidu S. Chowdari; Guofu Zhong; Juan M. Betancort; Fujie Tanaka; Carlos F. Barbas III


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
309 KB
Volume
346
Category
Article
ISSN
1615-4150

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Slow addition of a primary amine to the reaction mixture greatly increases the scope of the titanium-catalyzed asymmetric reduction of imines 1. An important added feature of this method is that chiral secondary amines 2 can be obtained in much higher optical purity (up to 99 % ee) than would be pre