Exogenous Triacylglycerol Inhibits Insulin-Stimulated Glucose Transport in L6 Muscle Cells in Vitro
β Scribed by G. Shillabeer; C. Chamoun; G. Hatch; D.C.W. Lau
- Book ID
- 115576185
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 405 KB
- Volume
- 207
- Category
- Article
- ISSN
- 0006-291X
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## Abstract We used nigericin, a K^+^/H^+^ exchanger, to test whether glucose transport in 3T3βL1 adipocytes was modulated by changes in intracellular pH. Our results showed that nigericin increased basal but decreased insulinβstimulated glucose uptake in a timeβ and doseβdependent manner. Whereas
Although the strongest evidenccl tor rc,cruitment of glucose transporters in response to insulin comes froin studies with adipocytes, studirs in muscle wem in general to confirm that gluc ose transporters dre a l w trdnslocdted to the cell membrane in muscle in rcyionse to iiiculin However, the obse