Excitotoxicity and Amyotrophic Lateral Sclerosis
β Scribed by Van Damme, P.; Dewil, M.; Robberecht, W.; Van Den Bosch, L.
- Book ID
- 115546241
- Publisher
- S. Karger AG
- Year
- 2005
- Tongue
- English
- Weight
- 338 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1660-2854
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π SIMILAR VOLUMES
## Abstract Excitotoxicity may play a role in certain disorders of the motor system thought to be caused by environmentally acquired toxins, including lathyrism and domoic acid poisoning. Motor neurons appear to be particularly susceptible to toxicity mediated via Ξ±βaminoβ3βhydroxyβ5βmethylβ4βisoxa
## Abstract In amyotrophic lateral sclerosis (ALS) nonβneuronal cells play key roles in disease etiology and loss of motoneurons via noncellβautonomous mechanisms. Reactive astrogliosis and dysfunctional transporters for Lβglutamate [excitatory amino acid transporters, (EAATs)] are hallmarks of ALS