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Excitotoxic Injury to Mitochondria Isolated from Cultured Neurons

✍ Scribed by Kushnareva, Y. E.

Book ID
127120040
Publisher
The American Society for Biochemistry and Molecular Biology
Year
2005
Tongue
English
Weight
781 KB
Volume
280
Category
Article
ISSN
0021-9258

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## Abstract The pathologic activation of NMDA receptors by glutamate is a major contributor to neuronal cell death after stroke. Receptor activation causes a massive influx of calcium into the neuron that is accumulated by the mitochondria. The favored hypothesis is that the calcium loaded mitochon