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Excitotoxic injury profiles of low-affinity kainate receptor agonists in cortical neuronal cultures

✍ Scribed by Randal X Moldrich; Nam S Cheung; Catherine J Pascoe; Philip M Beart

Book ID
114017393
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
118 KB
Volume
378
Category
Article
ISSN
0014-2999

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Low-affinity kainate receptor agonists induce insult-dependent apoptosis and necrosis in cultured murine cortical neurons
✍ Randal X. Moldrich; Philip M. Beart; Catherine J. Pascoe; Nam S. Cheung πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 355 KB

Overstimulation of ionotropic glutamate receptors leads to excitotoxic neuronal death, which has been implicated in the neurodegeneration of neurological diseases. The present study examined the role of putative low-affinity kainate receptor subtype (GluR5-7) agonists in excitotoxicity in cultured m