Excitant amino acids and audiogenic seizures in the genetically epilepsy-prone rat. II. Efferent seizure propagating pathway
โ Scribed by Maria H. Millan; Brian S. Meldrum; Cathy A. Boersma; Carl L. Faingold
- Book ID
- 115898449
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 694 KB
- Volume
- 99
- Category
- Article
- ISSN
- 0014-4886
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An excitant amino acid (EAA), N-methyl-D-aspartate (NMDA), induces susceptibility to seizures when bilaterally microinjected into subcortical auditory nuclei of normal rats. Thirty-five percent of animals exhibit only audiogenic seizures (AGS) after infusions of NMDA into inferior colliculus (IC). I
Genetically epilepsy-prone rats (GEPRs) which display tonic seizures (GEPR-9s) in response to acoustic stimulation were used in these studies. Other laboratories have shown that CEPR-9s have a reduced concentration of brain norepinephrine (NE). Previous reports have also indicated that audiogenie se