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Excitant amino acids and audiogenic seizures in the genetically epilepsy-prone rat. I. Afferent seizure initiation pathway

โœ Scribed by Carl L. Faingold; Maria H. Millan; Cathy A. Boersma; Brian S. Meldrum


Book ID
115898448
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
568 KB
Volume
99
Category
Article
ISSN
0014-4886

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Induction of audiogenic seizures in norm
โœ Carl L Faingold; Maria H Millan; Cathy A.Boersma Anderson; Brian S Meldrum ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 721 KB

An excitant amino acid (EAA), N-methyl-D-aspartate (NMDA), induces susceptibility to seizures when bilaterally microinjected into subcortical auditory nuclei of normal rats. Thirty-five percent of animals exhibit only audiogenic seizures (AGS) after infusions of NMDA into inferior colliculus (IC). I

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Genetically epilepsy-prone rats (GEPRs) which display tonic seizures (GEPR-9s) in response to acoustic stimulation were used in these studies. Other laboratories have shown that CEPR-9s have a reduced concentration of brain norepinephrine (NE). Previous reports have also indicated that audiogenie se