𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Exact Trait-Model-Free Tests for Linkage Detection in Pedigrees

✍ Scribed by S. Basu; Y. Di; E. A. Thompson


Book ID
111111435
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
134 KB
Volume
72
Category
Article
ISSN
0003-4800

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Power and robustness of linkage tests fo
✍ Wei-Min Chen; Karl W. Broman; Kung-Yee Liang πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 161 KB πŸ‘ 2 views

There are numerous statistical methods for quantitative trait linkage analysis in human studies. An ideal such method would have high power to detect genetic loci contributing to the trait, would be robust to non-normality in the phenotype distribution, would be appropriate for general pedigrees, wo

Score test for detecting linkage to comp
✍ J. Lebrec; H. Putter; J.C. van Houwelingen πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 844 KB

## Abstract We present a unified approach to selection and linkage analysis of selected samples, for both quantitative and dichotomous complex traits. It is based on the score test for the variance attributable to the trait locus and applies to general pedigrees. The method is equivalent to regress

Maximum-likelihood-binomial method for g
✍ Alexandre AlcaΓ―s; Laurent Abel πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 107 KB πŸ‘ 3 views

Sib-pair linkage studies are widely used to investigate the genetic factors implicated in complex quantitative traits. To analyze these data, we propose a Maximum-Likelihood-Binomial (MLB) approach, which considers the sibship as a whole and relies on the idea of binomial distributions of parental a