𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A Likelihood-Based Trait-Model-Free Approach for Linkage Detection of Binary Trait

✍ Scribed by S. Basu; M. Stephens; J. S. Pankow; E. A. Thompson


Book ID
109224205
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
191 KB
Volume
66
Category
Article
ISSN
0006-341X

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Maximum-likelihood-binomial method for g
✍ Alexandre AlcaΓ―s; Laurent Abel πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 107 KB πŸ‘ 3 views

Sib-pair linkage studies are widely used to investigate the genetic factors implicated in complex quantitative traits. To analyze these data, we propose a Maximum-Likelihood-Binomial (MLB) approach, which considers the sibship as a whole and relies on the idea of binomial distributions of parental a

The Maximum-Likelihood-Binomial method r
✍ Aurelie Cobat; Laurent Abel; Alexandre AlcaΓ―s πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 254 KB πŸ‘ 2 views

Model-free linkage analysis methods, based on identity-by-descent allele sharing, are commonly used for complex trait analysis. The Maximum-Likelihood-Binomial (MLB) approach, which is based on the hypothesis that parental alleles are binomially distributed among affected sibs, is particularly popul

Comparison of model-free linkage mapping
✍ C.I. Amos; J. Krushkal; T.J. Thiel; A. Young; D.K. Zhu; E. Boerwinkle; M. de And πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 76 KB πŸ‘ 2 views

We compared several strategies for identifying and estimating effects from a genetic locus in the etiology of a complex trait. For our analyses we used data from simulated trait 1 and chromosome 5. Results from analysis of the first 20 replicates showed that a components of variance test provided co