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Exact Confidence Bounds Following Adaptive Group Sequential Tests

✍ Scribed by Werner Brannath; Cyrus R. Mehta; Martin Posch

Book ID: 109224028
Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 168 KB
Volume: 65
Category: Article
ISSN: 0006-341X
DOI: 10.1111/j.1541-0420.2008.01101.x

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When the individual measurements are statistically independent, the maximum likelihood estimator of treatment e ect calculated at the end of a sequential procedure overestimates the underlying e ect. Lee and DeMets (1991. J. Amer. Statist. Assoc. 86, 757-762) proposed a group sequential method with