✦ LIBER ✦

Estimation following group sequential tests with repeated measurements data

✍ Scribed by Jae Won Lee; David L DeMets

Book ID: 104306932
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 88 KB
Volume: 32
Category: Article
ISSN: 0167-9473
DOI: 10.1016/s0167-9473(99)00021-3

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✦ Synopsis

When the individual measurements are statistically independent, the maximum likelihood estimator of treatment e ect calculated at the end of a sequential procedure overestimates the underlying e ect. Lee and DeMets (1991. J. Amer. Statist. Assoc. 86, 757-762) proposed a group sequential method with repeated measurements based on the linear mixed e ects model. In this article, we investigate by simulation the properties of the maximum likelihood estimator following group sequential tests with repeated measurements data.

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