Ex vivo evaluation of N-(3-[18F]fluoropropyl)-2β-carbomethoxy-3β-(4-fluorophenyl)nortropane in rats
✍ Scribed by Teija Koivula; Päivi Marjamäki; Merja Haaparanta; Veronica Fagerholm; Tove Grönroos; Tiina Lipponen; Outi Perhola; Jouko Vepsäläinen; Olof Solin
- Book ID
- 116799166
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 515 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0969-8051
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N-(3-[ 18 F]fluoropropyl)-2b-carbomethoxy-3b-(4-iodophenyl)nortropane ([ 18 F]FP-b-CIT) was synthesized in a two-step reaction sequence. In the first reaction, 1-bromo-3-(nitrobenzene-4-sulfonyloxy)-propane was fluorinated with no-carrieradded fluorine-18. The resulting product, 1-bromo-3-[ 18 F]-fl
A synthesis method has been developed for the labelling of N-(3-[ 18 F]fluoropropyl)-2b-carbomethoxy-3b-(4-fluorophenyl)nortropane ([ 18 F]b-CFT-FP), a potential radioligand for visualization of the dopamine transporters by positron emission tomography. The two-step synthesis includes preparation of