Evolutionary optimization of the catalytic efficiency of enzymes
✍ Scribed by Gösta PETTERSSON
- Book ID
- 115129318
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 767 KB
- Volume
- 206
- Category
- Article
- ISSN
- 1432-1327
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The distribution of the kinetic parameters of enzymic reactions is theoretically studied, on the assumption that, during evolution, the increase of reaction rates was an important target of natural selection. In extension of previous work on the optimization of enzyme kinetic parameters, the influen
Aside from the demonstration that individual molecular traits of enzymes can be evolutionarily optimised, the discovery that several traits can be simultaneously optimised is a major advance. The first observations of the effects of evolutionary optimisation at the structural level, through X-ray cr