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Evolutionary optimisation of enzymes

✍ Scribed by John D Sutherland

Book ID
104414421
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
150 KB
Volume
4
Category
Article
ISSN
1367-5931

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✦ Synopsis

Aside from the demonstration that individual molecular traits of enzymes can be evolutionarily optimised, the discovery that several traits can be simultaneously optimised is a major advance. The first observations of the effects of evolutionary optimisation at the structural level, through X-ray crystallography, reinforce the view that enzymes are best optimised by evolution and not by design.

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