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Evolution of the “titin epitope” in neurofilament proteins

✍ Scribed by Caterina Mencarelli; Barbara Magi; Barbara Marzocchi; Doretta Armellini; Vitaliano Pallini


Book ID
113323851
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
515 KB
Volume
100
Category
Article
ISSN
1096-4959

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Titin and twitchin are giant proteins expressed in muscle. They are mainly composed of domains belonging to the fibronectin class III and immunoglobulin c2 families, repeated many times. In addition, both proteins have a protein kinase domain near the C-terminus. This paper explores the evolution of