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Evolution of oncolytic adenovirus for cancer treatment

✍ Scribed by Joung-Woo Choi; Jung-Sun Lee; Sung Wan Kim; Chae-Ok Yun

Book ID
113418557
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
452 KB
Volume
64
Category
Article
ISSN
0169-409X

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## Abstract Treatment options for disseminated cervical cancer remain inadequate. Here, we investigated a strategy featuring Ad5‐Δ24RGD, an oncolytic adenovirus replication‐competent selectively in cells defective in the __Rb‐p16__ pathway, such as most cervical cancer cells. The viral fiber contai