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Evidence that extrachromosomal double-strand break repair can be coupled to the repair of chromosomal double-strand breaks in mammalian cells

✍ Scribed by Graham Dellaire; Ju Yan; Kevin C. Little; Régen Drouin; Pierre Chartrand

Publisher
Springer
Year
2002
Tongue
English
Weight
290 KB
Volume
111
Category
Article
ISSN
0009-5915

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The end-joining pathway of DNA double-strand break (DSB) repair is necessary for proper V(D)J recombination and repair of DSB caused by ionizing radiation. This DNA repair pathway can either use short stretches of (micro)homology near the DNA ends or use no homology at all (direct end-joining). We d