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Evidence that 3α-hydroxy-5α-pregnan-20-one is a physiologically relevant modulator of gaba-ergic neurotransmission

✍ Scribed by C. Hiemke; A. Jussofie; M. Jüptner

Book ID
119167106
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
514 KB
Volume
16
Category
Article
ISSN
0306-4530

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✍ Astrid Jussofie; Ibrahim Jussofie; Martin Stoppok; E. Rodney Lax 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 French ⚖ 152 KB 👁 1 views

## Abstract A procedure for the biosynthetic preparation of 3α‐hydroxy‐5α‐[1,2,6,7‐^3^H]‐pregnan‐20‐one (^3^H‐HPO) with high specific activity convenient for binding studies was developed. ^3^H‐HPO was synthesized from [1,2,6,7‐^3^H]progesterone using a microsomal preparation from rat liver and NAD