Evidence of the absence of Y fluorescent material in XX men
✍ Scribed by Kyra Michalová; Jiří Neuwirth; Jan Raboch
- Publisher
- Springer
- Year
- 1972
- Tongue
- English
- Weight
- 208 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0340-6717
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A search for Y-specific DNA sequences has been performed in a sample of seven 46,XX true hermaphrodites and one 45,X mixed gonadal dysgenesis case and compared with a sample of 11 XX males. Using six Y-specific DNA probes no hybridization signal was obtained in the hermaphrodite group; in contrast,
H-Y antigen expression was detected on cells from an individual having a presumptive 45,X/46,X,i(Yp) karyotype, but was absent on cells from another person having a 46,X,i(Yq) karyotype. This suggests that the short arm of the human Y chromosome is essential for H-Y antigen expression, at least in t