A mutant yeast constitutive for synthesis of both dihydroorotic acid dehydrogenase and orotidine 5' phosphate decarboxylase has been isolated. This phenotype is due to a single gene unlinked to any of the five genes of the pyrimidine pathway. This gene, called ppr1, induces the unlinked genes ural a
Evidence for transcriptional regulation of dihydroorotic acid dehydrogenase inSaccharomyces cerevisiae
✍ Scribed by G. Loison; R. Jund; M. Nguyen-Juilleret; F. Lacroute
- Publisher
- Springer-Verlag
- Year
- 1981
- Tongue
- English
- Weight
- 646 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0172-8083
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✦ Synopsis
Two yeast DNA fragments carrying the URA 1 gene have been isolated. URA 1 mRNA levels were measured in wild-type yeast and ppr 1 (constitutive for DHOdehase synthesis) strains. Results favour the hypothesis that ppr 1 increases the transcription of URA 1. The corresponding E. coli PYR D gene has also been cloned.
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