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Evidence for the role of a trypsin-like enzyme in the hamster sperm acrosome reaction

✍ Scribed by Meizel, Stanley ;Lui, Chung W.

Publisher
John Wiley and Sons
Year
1976
Tongue
English
Weight
306 KB
Volume
195
Category
Article
ISSN
0022-104X

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✦ Synopsis

Abstract

Acrosome reactions occurring in vitro in hamster sperm capacitated by bovine follicular fluid were severely inhibited by four synthetic trypsin inhibitors and by Zn^2^ +. Three polypeptide trypsin inhibitors and a synthetic chymotrypsin inhibitor did not inhibit the acrosome reaction, and Ca^2^ + overcame the inhibition by Zn^2^. These results suggest that a trypsin‐like enzyme (possibly acrosin) plays a role in the acrosome reaction.

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