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Evidence for the p53 tumour suppressor protein as a direct sensor of DNA damage

✍ Scribed by R. Bristow; S. Al-Rashid; F. Jalali; L. Lilge

Book ID
117658428
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
355 KB
Volume
37
Category
Article
ISSN
0959-8049

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## Abstract The p53 tumor suppressor gene, which is frequently mutated in a wide variety of tumors, plays an important role in maintaining genomic integrity. Following genotoxic insults, the protein level of p53 is increased, and p53 functions as a sequence‐specific transcription factor that regula