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Evidence for the involvement of a carboxyl group in the vicinity of the MK801 and magnesium ion binding site of the N-methyl-D-aspartate receptor

โœ Scribed by Paul L. Chazot; Alexandra Fotherby; F.Anne Stephenson


Book ID
115783226
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
665 KB
Volume
45
Category
Article
ISSN
0006-2952

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The novel anticonvulsant MK-801 binds to
โœ Alan C. Foster; Erik H.F. Wong ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› Nature Publishing Group ๐ŸŒ English โš– 1022 KB

The influence of endogenous and exogenous acidic amino acids on the binding of [3H]-MK-801, a selective, non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptors, has been inves- tigated in rat cerebral cortex crude synaptic membranes (CSM). 2 Removal of endogenous glutamate and aspartate