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(+)-3-[123I]Iodo-MK-801: Synthesis and characterization of binding to the N-methyl-D-aspartate receptor complex

โœ Scribed by Richard W. Ransom; Wai-si Eng; H.Donald Burns; Raymond E. Gibson; Howard F. Solomon


Book ID
118344405
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
628 KB
Volume
46
Category
Article
ISSN
0024-3205

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The novel anticonvulsant MK-801 binds to
โœ Alan C. Foster; Erik H.F. Wong ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› Nature Publishing Group ๐ŸŒ English โš– 1022 KB

The influence of endogenous and exogenous acidic amino acids on the binding of [3H]-MK-801, a selective, non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptors, has been inves- tigated in rat cerebral cortex crude synaptic membranes (CSM). 2 Removal of endogenous glutamate and aspartate