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Evidence for the interference of aluminum with bacterial porphyrin biosynthesis

✍ Scribed by Ram Scharf; Rivka Mamet; Yoram Zimmels; Shlomo Kimchie; Nili Schoenfeld

Book ID: 104638622
Publisher: Springer Netherlands
Year: 1994
Tongue: English
Weight: 479 KB
Volume: 7
Category: Article
ISSN: 1572-8773
DOI: 10.1007/bf00140483

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✦ Synopsis

Aluminum (0.74 mM) was found to retard bacterial growth, and enhance porphyrin formation and excretion in Arthrobacter aurescens RS-2. Coproporphyrin III was shown to be the main porphyrin excreted by aluminum-exposed A. aurescens RS-2 cultures and by RS-2 cultures grown under anoxic conditions. Synthesis and excretion of porphyrins in A. aurescens RS-2 increased in a dose-dependent manner when the bacteria were exposed to increasing aluminum concentrations. Incubation of A. aurescens RS-2 with b-aminolevulinic acid (t~-ALA, 1.2 mM) brought about the intense formation and excretion of porphyrins by the cells, in the presence or absence of aluminum. 6-ALA slightly enhanced the toxicity of aluminum towards RS-2 bacteria. Furthermore, the intracellular concentration of heme was reduced by 63.9 _ 8.67% in aluminum-exposed RS-2 bacteria when compared with control cultures. The results are discussed in light of the recent finding concerning aluminum toxicity and porphyrin biosynthesis in microorganisms.

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