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Evidence for the existence of multipotential lympho-hematopoietic stem cells in the adult rat

✍ Scribed by Peter C. Nowell; Bruce E. Hirsch; Dianne H. Fox; Darcy B. Wilson

Publisher
John Wiley and Sons
Year
1970
Tongue
English
Weight
731 KB
Volume
75
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

Rats were given near‐lethal doses of x‐ray to produce clones of hemic cells marked by radiation‐induced chromosome abnormalities. Subsequently, bone marrow from these rats was injected into lethally irradiated mice to form erythropoietic spleen colonies; and peripheral blood lymphocytes from the same rats were stimulated to proliferate in a mixed lymphocyte interaction (MLI), an immunological response to histocompatibility isoantigens.

Chromosome markers indicated that in several instances the cells of an erythroid spleen colony and a proportion of the lymphocytes reacting in the MLI were progeny of the same stem cell in the donor rat. In addition, lymphocytes of the same radiation‐marked clone were shown to proliferate in response to several different histocompatibility isoantigens. The data indicate the presence in the adult rat of a primitive lymphohematopoietic stem cell capable of yielding both erythroid and lymphoid progeny. The findings also suggest that immunological specificity is determined during lymphoid differentiation, subsequent to the stem cell stage.

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