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Evidence for the synthesis of embryonic globin chains in adult erythroid progenitor cells

✍ Scribed by Kabita Bhaumik

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 395 KB
Volume: 36
Category: Article
ISSN: 0361-8609
DOI: 10.1002/ajh.2830360105

No coin nor oath required. For personal study only.

✦ Synopsis

Embryonic globin chains were found to be synthesized in vitro by the BFU-E colonies derived from adult sickle cell anemia (SS) patients, their heterozygous relatives as well as a few normal controls. In the absence of sufficient material for conducting direct structural analyses of these peptides, they were confirmed by evaluating the co-migration of the epsilon and zeta-chains with the corresponding structurally characterized globin chains obtained from K562 cell lysates on a reversed phase high performance liquid chromatogram. The presence of zeta-chain was also confirmed using an immunologic procedure. Furthermore, significant 35S-methionine incorporation peak was observed corresponding to the zeta-chain synthesized by the BFU-E-derived colonies implying an active synthesis of this embryonic globin chain in BFU-E cells obtained from hemopoietically adult persons.

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