𝔖 Bobbio Scriptorium
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Evidence for the bioactive conformation in a cyclic hexapeptide analogue of somatostatin containing a cis-peptide bond mimic

✍ Scribed by M. Elseviers; L. Van Der Auwera; H. Pepermans; D. Tourwé; G. Van Binst


Book ID
115761068
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
339 KB
Volume
154
Category
Article
ISSN
0006-291X

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The cyclic hexapeptide cycle[ -Pro'-Gly2-Glu3 (OBzl) -Pro4-Phe5-Leu6-] ( 1 ; OBzl: benzyl ester) was modeled and synthesized to be used as a chiral site for the separation of enantiomers. Total correlation spectroscopy and nuclear Ovehauser effect spectroscopy spectra of the peptide in CDCIB showed