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Evidence for sulfhydryl groups at the active site of Catechol-O-Methyltransferase

โœ Scribed by Ronald T. Borchardt; Dhiren R. Thakker


Book ID
115734171
Publisher
Elsevier Science
Year
1976
Weight
703 KB
Volume
445
Category
Article
ISSN
0005-2744

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Molecular Recognition at the Active Site
โœ Manuel Ellermann; Roland Jakob-Roetne; Christian Lerner; Edilio Borroni; Daniel ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 562 KB

Biologically active catechols, such as l-DOPA and the neurotransmitter dopamine, are inactivated by methylation. This reaction is catalyzed by the enzyme catechol-O-methyltransferase (COMT) in the presence of S-adenosylmethionine (SAM) and Mg 2+ ions. [1] Small nitrocatechol-based inhibitors of COMT